Preparation of Realgar Nanoparticle Suspension and Its Inhibition Effect on the Proliferation of Human Myelocytic Leukaemia HL-60 Cells |
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| Authors: | Nan Wang Li-Wen Wang |
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| Institution: | 1. Department of Chemical Biology , Peking University School of Pharmaceutical Sciences , Beijing, P.R. China;2. Department of Chemical Biology , Capital Medical University School of Pharmaceutical Sciences , Beijing, P.R. China |
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| Abstract: | Realgar (As4S4) has recently been proved effective in the treatment of leukaemia in clinical trials. However, the poor solubility of realgar makes it difficult to conduct mechanistic study in cellular level. In this work, we prepared realgar nanoparticle (RNP) suspension and examined its effect on the proliferation of human myelocytic leukaemia HL-60 cells. The average diameter of the particles was 143 nm and was stable against coalescence over a 15-month storage. The suspension inhibited cell proliferation dose-dependently at concentrations from 10 to 60 µM (As), a fact shedding light on the mechanism of realgar's clinical effectiveness against hematopoietic malignancies. |
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| Keywords: | HL-60 leukaemia nanoparticle proliferation realgar |
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