Drug Surfactant and Polymer Mediated Acid Catalyzed Hydrolysis of Acetohydroxamic Acid |
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| Authors: | Santosh K Sar Pankaj Soni |
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| Institution: | 1. Department of Engineering Chemistry, Center for Environmental Science &2. Engineering, Bhilai Institute of Technology , Durg (C.G.), India santoshsar@hotmail.com;4. Engineering, Bhilai Institute of Technology , Durg (C.G.), India |
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| Abstract: | The effects of drug-surfactant and polymer on the acid hydrolysis of acetohydroxamic acid (AHA) have been studied at room temperature in 2% (v/v) dioxane medium. Kinetic data corresponding to the reaction with drug micelles are analyzed by using the pseudo-phase ion exchange model. The binding constant and first-order rate constant in micellar media in presence of AMYTP+-Drug, AMYTP+-β-Cyclodextrine, AMYTP+-SDS, AMYTP+-PEG, AMYTP+-TX-100, AMYTP+-CTAB, have been studied in 0.5 M HCl media. |
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| Keywords: | Acetohydroxmic acid acid-hydrolysis amitriptyline (AMYTP+) polymer-surfactant tri-cyclic antidepressant-drug |
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