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Liquid-Crystal Based Formulations for Topical Drug Delivery
Authors:Pradip Hiwale  Sandrina Lampis  Sergio Murgia
Institution:Department of Chemical and Geological Sciences , University of Cagliari, CNBS and CSGI, Cittadella Universitaria , Monserrato (CA) , Italy
Abstract:Monoolein, being a biocompatible and bioadhesive penetration enhancer that can form liquid crystalline (LC) phases, possesses remarkable characteristics for addressing drug delivery systems across the biological membrane. A range of formulations based on LC phases were investigated in this study, which includes lamellar, reverse hexagonal, and bicontinuous cubic phases along with an emulsion stabilized by LC phases. Caffeine was chosen as hydophilic model drug to evaluate in vitro release performance. The different monoolein based caffeine formulations were characterized by techniques such as polarized light microscopy, nuclear magnetic resonance (NMR) and small angle x-ray scattering (SAXS). The release experiments, performed through Franz diffusion cells, revealed that the presence of a liquid crystalline (LC) phase prevented burst release in all cases. In addition, taking into consideration that all ingredients are fully biocompatible, the creamy emulsion formulation stabilized by a hexagonal lipid LC phase can be proposed as a challenging preformulation for topical drug delivery. id=
Keywords:Caffeine  emulsions  in vitro release  liquid crystals  monoolein
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