| Molecular Mechanism of High Energy Proton Radiation——Raman Spectroscopic Character of Microcosmic Damage in the Space Structure of DNA |
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| 引用本文： | 许以明,张志义,赵克俭,张仲纶,刘成祥,王大辉,徐国瑞,郑雁珍.Molecular Mechanism of High Energy Proton Radiation——Raman Spectroscopic Character of Microcosmic Damage in the Space Structure of DNA[J].中国科学B辑(英文版),1993(11). |
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| 作者姓名： | 许以明 张志义 赵克俭 张仲纶 刘成祥 王大辉 徐国瑞 郑雁珍 |
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| 作者单位： | Institute of Biophysics，Academia Sinica，Beijing 100101，PRC，Institute of Biophysics，Academia Sinica，Beijing 100101，PRC，Institute of Biophysics，Academia Sinica，Beijing 100101，PRC，Institute of Biophysics，Academia Sinica，Beijing 100101，PRC，Institute of Biophysics，Academia Sinica，Beijing 100101，PRC，Institute of Biophysics，Academia Sinica，Beijing 100101，PRC，Institute of Biophysics，Academia Sinica，Beijing 100101，PRC，Institute of Biophysics，Academia Sinica，Beijing 100101，PRC |
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| 基金项目： | Project supported by the National Natursl Science Foundation of China. |
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| 摘 要： | High energy proton is an important type of the space radiation. The paper investigates the radiatione ffect of high energy proton (27.9 MeV) on DNA aqueous solution in the field of the molecular mechanism. The following information about the microcosmic damage to the space structure of DNA was obtained: (ⅰ) breakage of a part of interbase hydrogen bonds which maintained double helical structure of DNA; (ⅱ) damage on four bases, in which the damage on adenine ring was the most serious; (ⅲ) obvious change of deoxyribose; (ⅳ) serious damage on backbone phosphate ion (PO_2~-) and phosphate diester (PO_2) and the occurrence of scissions of double-stranded and single-stranded DNAs; (ⅴ) obvious decrease in the amount of B-form conformation.
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