硒代二半胱氨酸对白血病细胞系谷胱甘肽过氧化物酶的影响

观察了硒代二半胱氨酸对白血病细胞系（Ｕ９３７和Ｋ５６２）生长增殖和谷胱甘肽过氧化物酶的影响．结果表明，硒代二半胱氨酸抑制白血病细胞生长和增殖，其抑制作用与药物浓度呈正相关．经３．０μｍｏｌ／Ｌ（ＩＣ５０）硒代二半胱氨酸作用３天后（Ｕ９３７和Ｋ５６２白血病细胞内谷胱甘肽过氧化物酶活性显著提高（Ｐ＜０．０１），在培养第３天和第６天时无显著差别．谷胱甘肽过氧化物酶活性的提高有利于白血病细胞生长的抑制．

Regulation of Glutathione Peroxidase Activity by Dicysteine Selenium in Leukemia Cell Lines

Selenium exists in a number of forms with differing valence states, some on which have anti-tumor activity. In our laboratory, selenium compound-dicysteine selenium has been shown to inhibit growth and division of U937 and K562 leukemia cell lines in a dose dependent manner. Furthermore, the glutathione peioxidase activity was observed. Exposure of leukemia cell cultures to dicysteine selenium resulted in increment of glutethione peroxidase activity,when compared with the selenium-replete cell cultures, but non difference was found between that in 3 and 6 days.