| A cytotoxic compound from the leaves of Juglans mandshurica |
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| 作者姓名： | Zhi Bo Li Yong Ming Bao Hong Bo Chen Jing Yun Wang Jie Han Hu Li Jia An |
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| 作者单位： | [1]Department of Bioscience and Biotechnology, Dalian University of Technology, Dalian 116024, China [2]School of Chemical Engineering, Dalian University of Technology, Dalian 116024, China [3]Dalian Institute of Chemical Physics, The Chinese Academy of Sciences, Dalian 116011, China |
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| 摘 要： | From Juglans mandshurica leaves, a new quinone compound was isolated through bioassay-guided fractionation. The structure elucidation of the compound was established based on spectroscopic studies, notably of the 2D NMR spectra. The compound exhibited moderate cytotoxic activities against Hela, MCF-7, BGC823 and 3T3-Llcell lines with IC50 ranges from 7.5 to 26.8 μmol/L.
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| 关 键 词： | 细胞毒素 胡桃 中药 有效成分 根 茎 提取 |
| 收稿时间： | 12 March 2007 |
| 修稿时间： | 2007-03-12 |
A cytotoxic compound from the leaves of Juglans mandshurica |
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| Zhi Bo Li Yong Ming Bao Hong Bo Chen Jing Yun Wang Jie Han Hu Li Jia An.A cytotoxic compound from the leaves of Juglans mandshurica[J].Chinese Chemical Letters,2007,18(7):846-848. |
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| Authors: | Zhi Bo Li Yong Ming Bao Hong Bo Chen Jing Yun Wang Jie Han Hu Li Jia An |
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| Institution: | 1. Department of Bioscience and Biotechnology, Dalian University of Technology, Dalian 116024, China;2. School of Chemical Engineering, Dalian University of Technology, Dalian 116024, China;3. Dalian Institute of Chemical Physics, The Chinese Academy of Sciences, Dalian 116011, China |
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| Abstract: | From Juglans mandshurica leaves, a new quinone compound was isolated through bioassay-guided fractionation. The structure elucidation of the compound was established based on spectroscopic studies, notably of the 2D NMR spectra. The compound exhibited moderate cytotoxic activities against Hela, MCF-7, BGC823 and 3T3-L1cell lines with IC50 ranges from 7.5 to26.8 mmol/L. |
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| Keywords: | Juglans mandshurica p-Hydroxymethoxybenzobijuglone Cytotoxicity |
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