Potential analytical applications of gated artificial ion channels |
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| Authors: | L?Husaru R?Schulze G?Steiner T?Wolff W?D?Habicher Email author" target="_blank">R?SalzerEmail author |
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| Institution: | (1) Institute of Analytical Chemistry, Dresden University of Technology, 01062 Dresden, Germany;(2) Institute of Physical Chemistry, Dresden University of Technology, 01062 Dresden, Germany;(3) Institute of Organic Chemistry, Dresden University of Technology, 01062 Dresden, Germany |
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| Abstract: | Biosensors based on natural ion channels combine a biological recognition mechanism with a physical transduction technique in a very selective and sensitive manner. This kind of molecular sensor will contribute to drug screening and environmental screening. Key information about channel gating, ion transport, and molecular mechanism is provided by the patch-clamp technique, commonly used for electrophysiological analysis. Here we report the synthesis of light-gated artificial ion channels, necessary constituents for construction of biosensors based on natural ion channels. The artificial gated ion channels described here are based on calix4]resorcinarene. Opening and closing of the artificial ion channel is achieved by azo groups, which work like a lid. Azo groups alter their conformation on irradiation with light, and are chemically quite stable. Addition of a gate function will enhance the potential of synthetic channels to be used in sensors as molecular switches.Dedicated to the memory of Wilhelm Fresenius |
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| Keywords: | Gated calixresorcinarene Photo switch Ion channel |
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