高等真核生物基因组isochore边界确定中的对称性

高等真核生物基因组的isochore结构与许多重要的生物学特征相关,而对其边界的确定则是isochore结构分析的重点,同时也是难点.针对基于Z曲线的累积GC轮廓图法、基于Shannon熵的递归分段算法以及基于二次散度的分段算法三种典型的应用,分析出其分段依据本质上是对于基因组序列求取碱基对换对称性的对称中心.基于此结...

Measures of Symmetry in the Identifying Isochore Boundaries of Eukaryotic Genomes

Many higher eukaryotic genomes are composed of large sequence segments with fairly homogeneous GC content,namely isochores,which have been linked to many important biological functions.It is not only important but also difficult to determine the isohore boundaries.Three methods,GC-Profile algorithm based on Z curver,ecursive segmentation algorithm based on Shannon entropy and on quadratic divergence,are analyzed and conclusion is drawn that the common feature of three algorithms is to find the symmetry cent...