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The effect of thiolation on the mechanical and protein adsorption properties of polyurethanes |
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| Authors: | Sara Alibeik Kibret Mequanint |
| Institution: | a Graduate Program in Biomedical Engineering, The University of Western Ontario, London, Ont., Canada N6A5B9 b Department of Chemical and Biochemical Engineering, The University of Western Ontario, London, Ont., Canada N6A5B9 c Division of Biomaterials Science, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ont., Canada N6A5B9 |
| Abstract: | Segmented polyurethanes are important polymers for a number of industrial and technological applications. The purpose of this work was to synthesize polybutadiene-based polyurethanes and subsequently graft carboxylate and sulfonate side chains via thiol-ene reaction. Spectroscopic investigations showed that grafting yielded good conversion for the vinyl unsaturation of the polybutadiene soft segment. DSC and tensile testing revealed that grafted polyurethanes had a better segmental compatibility and superior mechanical properties than the control polyurethane without grafting. The carboxylic side chains of the soft segment were responsible for the observed improved mechanical properties. Initial protein adsorption tests on these polymers were found to be higher than the control surface. The polyurethanes of the current study could be used for biomedical applications where protein attachment to the surface is needed for specific cell adhesion and tissue repair. |
| Keywords: | Polyurethanes Thiol-ene reaction Mechanical properties Protein adsorption |
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