Novel fluorescent amphiphilic block copolymers: Controllable morphologies and size by self-assembly |
| |
Authors: | Xiaoju Lu Cheng Li Feng Liang Zhaoqiang Wu Lifen Zhang |
| |
Institution: | Department of Chemistry, Wuhan University, Wuhan 430072, PR China |
| |
Abstract: | New fluorescent amphiphilic copolymers polyacrylamide-b-poly(p-methacrylamido)acetophenone thiosemicarbazone (PAM-b-PMATC) were synthesized by atom transfer radical polymerization (ATRP) method. The structures of polymers were confirmed by 1H NMR and gel permeation chromatography-multi-angle laser light scatting (GPC-MALLS). PAM-b-PMATC showed a broad emission peak about 388 nm excited at 318 nm in aqueous solution. The self-assembly behavior of PAM-b-PMATC in the binary mixture formamide/water was observed by transmission electron microscope (TEM). It indicated that PAM-b-PMATC-I and -II with the same PAM block self-assembled to vesicles and sunflower-like micelles. The water fraction in the mixture could control the size and thickness of vesicles. Vesicle size increased from 50 to 420 nm and vesicle thickness changed from 5 to 50 nm with water content ranging from 33 to 90 vol.%. In addition, the cytotoxicity in vitro of PAM-b-PMATC-I and its nanoparticles loaded with methotrexate (MTX) were evaluated by MTT assay. |
| |
Keywords: | Amphiphilic copolymer Fluorescent Self-assembly Vesicles |
本文献已被 ScienceDirect 等数据库收录! |