d-Poly(lactide) and LHRH decapeptide stereointeractions investigated by vibrational spectroscopy |
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Authors: | Jianming Zhang Abraham J Domb Yukihiro Ozaki |
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Institution: | a Department of Chemistry, School of Science and Technology, Research Center for Environment Friendly Polymers, Kwansei-Gakuin University, Gakuen, Sanda 669-1337, Japan b Department of Medicinal Chemistry, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, P.O. Box 12065, Jerusalem 91120, Israel |
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Abstract: | The interactions between poly(d-lactic acid) (PDLA) and l-configured leuprolide (LHRH) to form heterocomplexes were investigated by a combination of infrared (IR), Raman and near infrared spectroscopy (NIR). It was found that an α crystal with 103 helical conformation of PDLA is formed in the PDLA/LHRH heterocomplexes with various LHRH loadings, whereas the secondary structures of LHRH in these heterocompelexes are greatly affected by the blend ratio of LHRH and PDLA. Based on the analysis of IR, Raman and NIR spectra of the various heterocomplexes, it is suggested that stereoselective Van der Waals interactions, consisting of interwined α helices of PDLA and LHRH, is responsible for the driving force of PDLA and LHRH stereocomplexation. To clarify the solid structure and the potential interaction in these heterocomplexes with various LHRH loadings, temperature-dependent IR spectral measurements were also employed. On the basis of the results presented, a model for the PDLA and LHRH stereointeraction process was proposed. |
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Keywords: | d-Lactic acid" target="_blank">d-Lactic acid l-Configured leuprolide" target="_blank">l-Configured leuprolide Heterocomplexes IR spectral measurements |
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