The effect of surface-modified nano-hydroxyapatite on biocompatibility of poly(ε-caprolactone)/hydroxyapatite nanocomposites |
| |
Authors: | Hong Jae Lee |
| |
Institution: | Nanomaterials Application Division, Korea Institute of Ceramic Engineering and Technology, 233-5 Gasan-Dong, Guemcheon-Gu, Seoul 153-801, Republic of Korea |
| |
Abstract: | We describe the effect of surface-modified hydroxyapatite (HAp) nano-crystals on biocompatibility of a new-type nanocomposite consisting of poly(ε-caprolactone) (PCL) and HAp. Surface-modified hydroxyapatite (HAp) nano-crystals were prepared by chemically grafting PCL on HAp surfaces. Time-dependent phase monitoring indicated that PCL surface-grafting contributed to the enhanced dispersion of HAp at nano-level in the PCL solution. The protein adhesion and cell experiments showed that the presence of PCL-grafted HAp nano-crystals in nanocomposites contributed to the enhanced biocompatibility. PCL-grafted HAp in nanocomposites provided more favorable environments for protein adsorption, compared with unmodified HAp. Nanocomposites containing PCL-grafted nanophase HAp showed positive effects on adhesion and proliferation of NIH3T3 fibroblasts. |
| |
Keywords: | Hydroxyapatite Surface modification Nanocomposites Poly(ε-caprolactone) Grafting |
本文献已被 ScienceDirect 等数据库收录! |