Thiamine diphosphate adenylyl transferase from E. coli: functional characterization of the enzyme synthesizing adenosine thiamine triphosphate |
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| Authors: | Alexander F Makarchikov Alain Brans Lucien Bettendorff |
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| Affiliation: | 1.Center for Cellular and Molecular Neurobiology,University of Liège,Liège,Belgium;2.Chemical Department,Grodno State Agricultural University,Grodno,Belarus;3.Center for Protein Engineering,University of Liège,Liège,Belgium |
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| Abstract: | Background We have recently identified a new thiamine derivative, adenosine thiamine triphosphate (AThTP), in E. coli. In intact bacteria, this nucleotide is synthesized only in the absence of a metabolizable carbon source and quickly disappears as soon as the cells receive a carbon source such as glucose. Thus, we hypothesized that AThTP may be a signal produced in response to carbon starvation. |
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