Asymmetric Synthesis of Trifluoromethylated Amines via Catalytic Enantioselective Isomerization of Imines |
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Authors: | Yongwei Wu Li Deng |
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Institution: | Department of Chemistry, Brandeis University , Waltham, Massachusetts 02454-9110, United States. |
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Abstract: | A new approach toward the asymmetric synthesis of optically active trifluoromethylated amines was enabled by an unprecedented, highly enantioselective catalytic isomerization of trifluoromethyl imines with a new chiral organic catalyst. Not only aryl but also alkyl trifluoromethylated amines could be obtained in high enantioselectivities. |
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