Palladium-assisted regioselective C-h cyanation of heteroarenes using isonitrile as cyanide source |
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| Authors: | Shuguang Xu Xiaomei Huang Xiaohu Hong Bin Xu |
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| Institution: | Department of Chemistry, Shanghai University, Shanghai 200444, China, State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China, and Shanghai Key Laboratory of Green Chemistry and Chemical Processes, Department of Chemistry, East China Normal University, Shanghai 200062, China. |
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| Abstract: | A palladium-catalyzed regioselective C-H cyanation of heteroarenes was achieved using tert-butyl isocyanide as "CN" source, which provides a new and unique strategy for the preparation of (hetero)aryl nitriles. Indoles, pyrroles, and aromatic rings could be efficiently cyanated through C-H bond activation with high regioselectivity. |
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