Parallel Microflow Photochemistry: Process Optimization, Scale-up, and Library Synthesis |
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| Authors: | Alexander Yavorskyy Oksana Shvydkiv Norbert Hoffmann Kieran Nolan Michael Oelgemöller |
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| Affiliation: | Dublin City University , School of Chemical Sciences, Dublin 9, Ireland, UMR 7312 CNRS et Université de Reims Champagne-Ardenne , Institut de Chimie Moléculaire de Reims, UFR Sciences, B.P. 1039, 51687, Reims, Cedex 02, France, and James Cook University , School of Pharmacy and Molecular Sciences, CBMDT, Townsville, Queensland 4811, Australia. |
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| Abstract: | A novel, multimicrocapillary flow reactor (MμCFR) was constructed and applied to a series of sensitized photoadditions involving 2(5H)-furanones. The reactor allowed for rapid and energy-, time-, and space-efficient sensitizer screening, process optimization, validation, scale-up, and library synthesis. |
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