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Benzoylphosphonate-Based Photoactive Phosphopeptide Mimetics for Modulation of Protein Tyrosine Phosphatases and Highly Specific Labeling of SH2 Domains |
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| Authors: | André Horatscheck Stefan Wagner Jutta Ortwein Boo Geun Kim Michael Lisurek Samuel Beligny Anja Schütz Jörg Rademann |
| Affiliation: | 1. Medizinische Chemie, Institut für Pharmazie, Universit?t Leipzig, Brüderstrasse 34, 04103 Leipzig (Germany) http://www.uni‐leipzig.de/agrademann;2. Abteilung für Medizinische Chemie, Leibniz‐Institut für Molekulare Pharmakologie (FMP), Robert‐R?ssle‐Strasse 10, 13125 Berlin (Germany);3. Helmholtz Protein Production Facility, Max‐Delbrück Center für Molekulare Medizin, Robert‐R?ssle‐Strasse 10, 13125 Berlin (Germany) |
| Abstract: | A light switch for phosphotyrosine- recognizing proteins: Irradiation of the bioisosteric benzoylphosphonate suffices to "turn off" the activity of target proteins and to label them covalently. Photoactive bioisosters may find applications in functional cell biology, bioanalytics, and proteome research. |
| Keywords: | phosphotyrosine isosters photoaffinity labeling photochemistry proteins protein tyrosine phosphatases |
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