Fischer indole synthesis in low melting mixtures |
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Authors: | Sangram Gore Sundarababu Baskaran Burkhard König |
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Affiliation: | Department of Chemistry, Indian Institute of Technology-Madras, Chennai 600036, India and Institut für Organische Chemie, Universit?t Regensburg, D-93040, Regensburg, Germany. |
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Abstract: | Functionalized indoles are synthezised under mild conditions in a tartaric acid-dimethylurea melt. The melt serves as the solvent and as the catalyst. Under these reaction conditions, sensitive functional groups such as N-Boc, N-Cbz, or azides are stable, and indolenines are obtained regioselectively in excellent yields. The practical use of the method is demonstrated in the synthesis of the hormone melatonin. |
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