Constituents of Hypericum laricifolium and their cyclooxygenase (COX) enzyme activities |
| |
Authors: | El-Seedi Hesham Rushdey Ringbom Therese Torssell Kurt Bohlin Lars |
| |
Affiliation: | Division of Pharmacognosy, Department of Medicinal Chemistry, Biomedical Centre, Uppsala University, Sweden. Hesham.El-Seedi@fkog.uu.se |
| |
Abstract: | Investigation of the aerial parts of the medicinal plant Hypericum laricifolium led to the isolation of two new natural products, hentriacontanyl caffeate (1a), nonacosanyl caffeate (1b). In addition, stigmasterol, beta-sitosterol, 3-epi-betulinic acid (2), caffeic acid (3), ferulic acid, docosanol, p-hydroxybenzoic acid, 3,4-dimethoxy benzoic acid, quercetin (4), quercetin-3-O-galactoside (5), quercetin-3-O-rutinoside (6), quercetin-3-O-rhamnoside (7), quercetin-3-O-glucuronide (8) and shikimic acid were also isolated. The structures were determined by 1D- and 2D-NMR, mass spectrometry, and chemical transformations. The anti-inflammatory effects of the isolated compounds were discussed briefly. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|