Chronic NMDA administration to rats increases brain pro-apoptotic factors while decreasing anti-Apoptotic factors and causes cell death |
| |
| Authors: | Hyung-Wook Kim Yunyoung C Chang Mei Chen Stanley I Rapoport Jagadeesh S Rao |
| |
| Institution: | (1) Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, 20892 Bethesda, MD, USA |
| |
| Abstract: | Background Chronic N-Methyl-D-aspartate (NMDA) administration to rats is reported to increase arachidonic acid signaling and upregulate neuroinflammatory
markers in rat brain. These changes may damage brain cells. In this study, we determined if chronic NMDA administration (25
mg/kg i.p., 21 days) to rats would alter expression of pro- and anti-apoptotic factors in frontal cortex, compared with vehicle
control. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
