A highly sensitive two-photon fluorescent probe for mitochondrial zinc ions in living tissue |
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| Authors: | Baek Na Young Heo Cheol Ho Lim Chang Su Masanta Goutam Cho Bong Rae Kim Hwan Myung |
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| Institution: | Division of Energy Systems Research and Molecular Science & Technology Research Center, Ajou University, Suwon, 443-749, Korea. |
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| Abstract: | We report a highly sensitive two-photon probe (SZn2-Mito) which shows a 70-fold two-photon excited fluorescence enhancement in response to Zn(2+) and can selectively detect mitochondrial Zn(2+) in a rat hippocampal slice at a depth of 100-200 μm by using two-photon microscopy. |
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