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Headspace SPME–GC Method for Acetone Analysis and its Biomedical Application |
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| Authors: | Amir Abbas Matin Ramin Maleki Mir Ali Farajzadeh Khalil Farhadi Reza Hosseinzadeh Abolghasem Jouyban |
| Affiliation: | (1) Research Department of Chromatography, Iranian Academic Center for Education, Culture and Research (ACECR), Urmia Branch, Urmia, Iran;(2) Department of Chemistry, Faculty of Science, Urmia University, Urmia, Iran;(3) School of Pharmacy and Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, 51664, Iran |
| Abstract: | A new method for extraction and analysis of acetone in human urine based on headspace solid phase microextraction using a mixture of activated carbon and zeolite as sorbents in a PVC matrix coated on a silver wire and its application to the determination of ketone bodies is described. Unlike commercial fibers, which are coated on fused silica, the coating adheres strongly to the silver wire and is thermally stable up to 250 °C. After optimization of coating composition and microextraction conditions the fiber was used for the analysis of acetone in human urine. |
| Keywords: | Gas chromatography Headspace-solid phase microextraction Silver wire Acetone in urine |
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