The applications of near-infrared Fourier transform Raman spectroscopy to the analysis of polymorphic forms of cimetidine |
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| Institution: | 1. Faculdade de Belas-Artes da Universidade de Lisboa, Largo da Academia Nacional de Belas-Artes, 1249-058, Lisboa, Portugal;2. HERCULES Laboratory, University of Évora, Palácio do Vimioso, Largo Marquês de Marialva 8, 7000-809 Évora, Portugal;3. Larsson Conservação e Restauro, Lda., Rua do Carmo, 90 4°, 1200-094, Lisboa, Portugal;4. Fundação Calouste Gulbenkian, Av. de Berna 45 A, 1067-001, Lisboa, Portugal;5. Laboratório de Instrumentação, Engenharia Biomédica e Física da Radiação (LIBPhys-UNL), Faculdade de Ciências e Tecnologias, Departamento de Física , Universidade Nova de Lisboa, 2829-516 Monte da Caparica, Portugal |
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| Abstract: | Fourier transform (FT)-Raman spectroscopy, utilizing a near-infrared (Nd:YAG laser, at 1.064 μm) source was used to characterise the three anhydrous polymorphic forms A, B and C of the drug cimetidine (N″-cyano-N-methyl-N′ -2-(5-methyl-1H-imidazol-4-yl) methylthio]ethyl]guanidine). The FT-Raman spectra were free from fluorescence interference and had good signal-to-noise ratios. Each polymorph has a distinct spectrum, characterised by two regions, 1250-1050 cm?1 and 1500-1350 cm?1. This work demonstrates that it is possible to use FT-Raman spectroscopy to differentiate between polymorphic forms of the same compound. |
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