Near infrared fourier transform Raman spectroscopy of human artery |
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| Affiliation: | 1. Department of Pharmaceutical Sciences, School of Pharmacy, The University of Jordan, Queen Rania St, Amman, 11942, Jordan;2. Faculty of Pharmacy, Philadelphia University, 19392, Amman, Jordan;3. Department of Obstetrics and Gynaecology, School of Medicine, The University of Jordan, 11942, Amman, Jordan;4. SESAME Synchrotron (Synchrotron-light for Experimental Science and Applications in the Middle East), 19252, Allan, Jordan;5. Department of Physics, Faculty of Science, Helwan University, Cairo, Egypt;1. Cinvestav Unidad Querétaro, Libramiento norponiente 2000, Fracc. Real de Juriquilla, Querétaro, Qro. 76230, Mexico;2. Cinvestav Unidad Saltillo, Industria Metalurgica No. 1062, Parque Industrial Saltillo-Ramos Arizpe, Ramos Arizpe 25900, Mexico;3. Universidad Michoacana de San Nicolás de Hidalgo, Ciudad Universitaria Morelia, Mich. 58060, Mexico;4. Nanotechnology Program, Universidad Autonoma de Queretaro, Querétaro, Qro. 76010, Mexico;5. Physics Institute UNAM, Av. Universidad 3000, Circuito Exterior S/N, Mexico, DF 04510, Mexico;6. Research Center for Exotic Nanocarbons (JST), Shinshu University, Wakasato 4-17-1, Nagano City 380-8553, Japan;7. Department of Physics and Materials Research Institute, The Pennsylvania State University, 104 Davey Laboratory, University Park 16802, USA;8. Universidad de Guadalajara, Department of Chemical Engineering, Av. Juarez 976, Guadalajara, Jal. 44100, Mexico;9. Department of Chemical Engineering, The University of Texas at Austin, Austin, TX 78703, USA;1. Bioactive Molecules Research Laboratory, Faculty of Sciences, Lebanese University, Lebanon;2. Laboratoire d’Automatique et de Génie des Procédés (LAGEP), UMR-CNRS 5007, Université Claude Bernard Lyon 1, CPE Lyon, Bat 308G, 43 Boulevard du 11 Novembre 1918, F-69622 Villeurbanne Cedex, France;1. College of Physics, Optoelectronics and Energy, Soochow University, Suzhou 215123, China;2. College of Physics & Electronic Engineering, Changshu Institute of Technology, Changshu 215500, China;3. Key Lab of Modern Optical Technologies, Soochow University, Suzhou 215006, China;1. Department of Physics, AEC, P. O. Box 6091, Damascus, Syria;2. Higher Institute for Laser Rtaesearch and Applications, Damascus University, Syria |
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| Abstract: | We report the first near IR FT-Raman spectroscopy of normal diseased human artery. In normal human aorta, two bands at 1669 cm−1 and 1452 cm−1 dominate the spectrum and can be assigned to protein amide I and C-H in-plane bending vibrations, respectively. Weaker bands are also observed between 1250 and 1350 cm−1. Non-calcified atherosclerotic lesions with a large amount of necrotic debris below the tissue surface show a relative increase in the intensity of the 1452 cm−1 band. In atherosclerotic aortas which contain calcified deposits several hundred microns below the tissue surface, a strong 961 cm−1 band is observed due to the symmetric stretch of phosphate groups in the calcified salts. The results show that this method provides the capability to probe biological substituents several hundred microns below the tissue surface. |
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