Enantioselective iridium-catalyzed allylic substitutions with hydroxamic acid derivatives as N-nucleophiles |
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Authors: | Gärtner Martin Jäkel Mascha Achatz Manuel Sonnenschein Christoph Tverskoy Olena Helmchen Günter |
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Institution: | Organisch-Chemisches Institut der Ruprecht-Karls-Universita?t Heidelberg, Heidelberg, Germany. |
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Abstract: | Enantioselective Ir-catalyzed allylic aminations with hydroxamic acid derivatives are described. Catalysts were prepared in situ from Ir(cod)Cl](2) or Ir(dbcot)Cl](2), a phosphoramidite and base. In addition, pure (π-allyl)Ir complexes containing cod or dbcot as auxiliary ligands were used. Very high degrees of regio- and enantioselectivity were achieved. The reaction products were transformed into piperidine derivatives suited as precursors for aza-sugars. |
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