Three-component tandem reaction involving acid chlorides, terminal alkynes, and ethyl 2-amino-1H-indole-3-carboxylates: synthesis of highly diversified pyrimido[1,2-a]indoles via sequential Sonogashira and [3+3] cyclocondensation reactions |
| |
| Authors: | Sahaj GuptaSudhir K. Sharma Anil K. MandadapuHarsh M. Gauniyal Bijoy Kundu |
| |
| Affiliation: | a Medicinal and Process Chemistry Division, Central Drug Research Institute, CSIR, Lucknow 226001, India
b Sophisticated Analytical Instrument Facility, Central Drug Research Institute, CSIR, Lucknow 226001, India |
| |
| Abstract: | A simple, highly efficient three-component reaction involving acid chlorides, terminal alkynes, and ethyl 2-amino-1H-indole-3-carboxylates, for the synthesis of highly diversified pyrimido[1,2-a]indoles has been described. The salient feature of the reaction involves sequential Sonogashira and [3+3] cyclocondensation reactions. |
| |
| Keywords: | Pyrimido[1,2-a]indoles Alkynes Ethyl 2-amino-1H-indole-3-carboxylate Multicomponent reaction Sonogashira coupling |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
