| Synthesis and Crystal Structure of 2,3,4,6-tetra-O-Acetyl-1-{4-chloro-3-[1-（4-ethoxyphenyl）-1-methylethyl]phenyl}-1-deoxy-β-D-glucopyranose |
| |
| 作者姓名： | 史永恒 赵桂龙 邵华 王玉丽 刘巍 汤立达 |
| |
| 作者单位： | [1]Tianjin Key Laboratory of Molecular Design and Drug Discovery,Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China [2]School of Pharmaceutical Science, Tianjin Medical University, Tianjin 300070, China |
| |
| 基金项目： | Supported by Key Projects of Tianjin Science and Technology Support Plan （10ZCKFSH01300） |
| |
| 摘 要： | The title compound was synthesized and its crystal structure was determined by single-crystal X-ray diffraction.The crystal is of monoclinic system(C31H37ClO10,Mr = 605.06),space group P21 with a = 11.882(5),b = 10.106(5),c = 13.816(6),V = 1545.9(12)3,Z = 2,Dc = 1.300 g/cm3,F(000) = 640,μ = 0.179 mm-1,the final R = 0.0430 and wR = 0.0595 for 4960 observed reflections(I > 2σ(I)).The title compound was confirmed to be a β-anomer by single-crystal X-ray diffraction and 1H NMR.The proximal benzene ring is nearly orthogonal to the glucopyranoside ring,and the two benzene rings are also almost orthogonal to each other.Four non-classical intermolecular hydrogen bonds observed in the crystal lattice help to stabilize the crystal.
|
| 关 键 词： | synthesis crystal structure C-glucoside SGLT2 inhibitor gem-dimethyl |
| 本文献已被 CNKI 维普 等数据库收录！ |
|
