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Synthesis of alkaloid-like compounds via the bridging Ritter reaction |
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| Authors: | Chulida Hemtasin Alison T. Ung Somdej Kanokmedhakul Kwanjai Kanokmedhakul Roger Bishop Thanaphat Satraruji David Bishop |
| Affiliation: | (1) School of Chemistry and Forensic Science, University of Technology, Broadway, P.O. Box 123, Sydney, NSW, 2007, Australia;(2) Natural Products Research Unit, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen, 40002, Thailand;(3) School of Chemistry, University of Wollongong, Wollongong, NSW, 2522, Australia;(4) School of Chemistry, The University of New South Wales, UNSW, Sydney, 2052, Australia; |
| Abstract: | AbstractAlkaloid-like compounds containing a benzo[c]azepine core structure were successfully prepared in three steps from 5H-dibenzo[a,d]cyclohepten-5-ol via the bridging Ritter reaction. Biological studies of these compounds revealed that some of them are AChE inhibitors and antimalarial agents. |
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