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Imatinib mesylate cocrystals: synthesis, screening, and preliminary characterization |
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| Authors: | Miroslav Veverka Peter ?imon Ján Gallovi? Vladimír Jorík Eva Veverková Tibor Dubaj |
| Institution: | 1. Research and Development Department, BelNovamann Ltd., 820 04, Bratislava, Slovakia 2. Faculty of Chemical and Food Technology, Institute of Physical Chemistry and Chemical Physics, Slovak University of Technology, Radlinského 9, 812 37, Bratislava, Slovakia 3. Faculty of Chemical and Food Technology, Institute of Inorganic Chemistry, Slovak University of Technology, Radlinského 9, 812 37, Bratislava, Slovakia 4. Faculty of Natural Sciences, Comenius University, 842 15, Bratislava, Slovakia |
| Abstract: | AbstractDrug–drug cocrystals of imatinib mesylate with several cocrystal formers, i.e. 5-chlorouracil, 5-fluorouracil, hydroxyurea, 5-fluorocytosine, N-acetylcytosine, chlorogenic acid, dacarbazine, curcumin, creatine, orotic acid, l-cysteine, glutathione, and caffeic acid, were prepared from mixtures by cogrinding or solvent cocrystallization. The samples prepared were analyzed by FTIR, DSC, and XRPD. Formation of cocrystals with different stoichiometry was observed. Novel cocrystals of imatinib mesylate with 5-fluorouracil or hydroxyurea were identified, characterized, and selected by the solid form screening approach. These cocrystals were non-hygroscopic and chemically and physically stable to thermal stress under the testing conditions. |
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