Thermal analysis and crystallization from melts |
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| Authors: | J Canotilho R A E Castro M T S Rosado S C C Nunes M S C Cruz J S Redinha |
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| Institution: | (1) Department of Chemistry, University of Coimbra, Rua Larga, 3004-535 Coimbra, Portugal;(2) Faculty of Pharmacy, University of Coimbra, Rua do Norte, 3000-295 Coimbra, Portugal; |
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| Abstract: | The growth of atenolol, pindolol and betaxolol hydrochloride from melt was investigated by differential scanning calorimetry
(DSC) and polarized light thermal microscopy (PLTM). Phase transitions occurring on cooling and subsequent reheating runs
performed between −160 °C and a temperature above the respective melting points were studied by DSC. The thermal cycles were
also followed by PLTM. Details about the dynamic of the crystallization front taken from microscopic observations are given.
An explanation of the results on the basis of molecular supramolecular recognition is advanced. |
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