A Ferroptosis-Inducing Arsenene-Iridium Nanoplatform for Synergistic Immunotherapy in Pancreatic Cancer |
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| Authors: | Xinyang Zhao Xingyun Wang Wei Zhang Tian Tian Jingyi Zhang Jing Wang Prof. Wei Wei Prof. Zijian Guo Prof. Jing Zhao Xiuxiu Wang |
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| Affiliation: | 1. Chemistry and Biomedicine Innovation Center (ChemBIC), State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210023 China;2. School of Life Sciences, Nanjing University, Nanjing, 210023 China These authors contributed equally.;3. School of Life Sciences, Nanjing University, Nanjing, 210023 China |
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| Abstract: | Due to multidrug resistance and the high risk of recurrence, effective and less toxic alternative pancreatic cancer treatments are urgently needed. Pancreatic cancer cells are highly resistant to apoptosis but sensitive to ferroptosis. In this study, an innovative nanoplatform ( AsIr@PDA ) was developed by electrostatic adsorption of a cationic iridium complex ( IrFN ) onto two-dimensional (2D) arsenene nanosheets. This nanoplatform exhibits superior ferroptosis-inducing effects with high drug loading capacity and, importantly, excellent anti-cancer immune activation function, leading to efficient elimination of pancreatic tumors with no observable side effects. Interestingly, AsIr@PDA significantly prevents the recurrence of pancreatic cancer in vivo when compared with a cisplatin-loaded nanoplatform. This designed nanoplatform demonstrated superior therapeutic efficacy by synergistic ferroptosis-induced chemotherapy with immunotherapy via an all-in-one strategy, providing new insights for future pancreatic cancer therapy. |
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| Keywords: | arsenene iridium ferroptosis immunogenic cell death pancreatic cancer |
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