Acute effects of exercise on muscle MRI in peripheral arterial occlusive disease |
| |
| Affiliation: | 1. Neurogenetics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA;2. Imanova Centre for Imaging Sciences, Hammersmith Hospital, London W12 0NN, UK;3. Experimental Medicine Imaging, Experimental Medicine Unit, GlaxoSmithKline, Middlesex UB11 1BT, UK;1. Department of Radiology, University of California Los Angeles, Los Angeles, CA, USA;2. Department of Neurology, University of California Los Angeles, Los Angeles, CA, USA;3. Department of Rheumatology, Harbor-UCLA Medical Center, Los Angeles, CA, USA;4. Biogen Idec, Cambridge, MA, USA;5. Department of Radiology, State University of New York at Stony Brook, Stony Brook, NY, USA |
| |
| Abstract: | The midcalf muscles of eight patients who had peripheral arterial occlusive disease were evaluated by exercise MRI before and after bypass surgery or percutaneous transluminal angioplasty. MRI showed a high intensity of these muscles, especially the posterior muscles, after exercise in all patients before intervention. The mean T2 relaxation time was maximal immediately after exercise (tibialis anterior, T2 = 30.8 ms; soleus, T2 = 36.2 ms; gastrocnemius, T2 = 32.8 ms) and then gradually decreased to the preexercise level. The difference in the T2 relaxation time of the soleus between immediately after exercise and at rest was smaller along with improvement of ankle pressure indices (API) after successful intervention (mean T2 difference: 4.91 and 0.72 ms (p < .001); mean API: 0.54 and 0.86 (p < .001) before and after intervention, respectively). The mean resting midcalf T2 relaxation time was significantly higher after intervention (tibialis anterior, T2 = 28.4 and 29.5 ms (p < .05); soleus, T2 = 31.4 and 32.9 ms (p < .05); gastrocnemius, T2 = 29.5 and 31.1 ms (p < .01) before and after intervention, respectively). T2 relaxation time may be a useful quantitative parameter in peripheral arterial occlusive disease as well as in other muscle studies. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
