Electron beam potential depression as an ion trap in Fourier transform ion cyclotron resonance mass spectrometry |
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| Institution: | 1. Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA;2. Institute of Pharmaceutical Chemistry, Goethe University, Frankfurt am Main, Germany;3. Structural Genomics Consortium, BMLS, Frankfurt am Main, Germany;4. Institute of Biophysical Chemistry and Center for Biomolecular Magnetic Resonance, Goethe University, Frankfurt am Main, Germany;5. Department of Theoretical Biophysics, Max Planck Institute of Biophysics, Frankfurt am Main, Germany;6. Department of Cell Biology, Harvard Medical School, Boston, MA, USA;7. Institute of Biophysics, Goethe University, Frankfurt am Main, Germany;1. Department of Mathematical Sciences, University of Cincinnati, Cincinnati, OH, USA;2. Laboratory of Mathematics and Complex Systems (Ministry of Education), School of Mathematical Sciences, Beijing Normal University, Beijing, People''s Republic of China;1. US Oncology Research, LLC, McKesson Specialty Health, The Woodlands, TX;2. Texas Oncology, Central Austin Cancer Center, Austin, TX;3. US Oncology Research/Comprehensive Cancer Centers NV, Las Vegas, NV;4. Yale Cancer Center, New Haven, CT;5. US Oncology Research/Willamette Valley Cancer Institute, Eugene, OR;6. Exelixis, South San Francisco, CA;7. HonorHealth Research Institute, Scottsdale, AZ;8. University of California, Davis, CA;1. School of Mathematical Sciences, Fudan University, Handan Road 220, Shanghai 200433, China;2. School of Mathematical Sciences and Shanghai Key Laboratory for Contemporary Applied Mathematics, Fudan University, Handan Road 220, Shanghai 200433, China;3. Key Laboratory of Mathematics for Nonlinear Sciences (Fudan University), Ministry of Education, Handan Road 220, Shanghai 200433, China;1. Department of Endocrinology, The 2nd Clinical Medical College of Jinan University, Shenzhen People''s Hospital, Shenzhen, China;2. Department of Pharmacological Sciences, Key Laboratory of Metabolism and Regulation for Major Diseases of Anhui Higher Education Institutes, College of Food and Biological Engineering, Hefei University of Technology, Hefei, China;3. First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China;4. Department of Biochemistry and Molecular Biology, College of Life Science, State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials of Ministry of Education, Nankai University, Tianjin, China;5. Buchang Pharmaceutical Co. Ltd., Xi’an, China;6. Tianjin University of Traditional Chinese Medicine, Tianjin, China;1. Departamento de Matemática, Universidade Federal do Rio Grande do Sul, Av. Bento Gonçalves 9500, CEP 91509-900, Porto Alegre, RS, Brazil;2. Department of Mathematics, University of Rijeka, Croatia;3. Department of Mathematics, National Taiwan University, Taipei, Taiwan |
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| Abstract: | Trapping of ions in the electron beam of a FTICR mass spectrometer is investigated and a simple model describing the confinement process is presented. Detection of resistive-wall destabilization of the magnetron motion of ions in the trapped-ion cell is used to determine conditions for ion trapping within and escape from the electron beam. The model predicts a potential well that is dependent on electron beam current, energy, and dimension in defining its capacity for low energy ions. Plots of ion retention time versus ion number are consistent with a model in which ions are initially trapped in the electron beam but with increasing ion formation will eventually overcome the potential depression in the electron beam and escape into magnetron orbits. Based upon this model, expressions are derived for ion retention time which are then fit to the experimental data. The model is used to estimate ion number, initial magnetron radius and ion cloud shape and density. One example in which electron trapping is important in the FTICR experiment is in the efficient transfer of ions between dual trapped-ion cells. Ion transfer within the potential depression of the electron beam environment is shown to be virtually 100% efficient over a 10 ms interval whereas all ions are lost to collisions with the conductance limit after 2 ms when transferring without the confining aid of the electron beam. Several analytical applications of electron traps in the ICR cell are now being investigated. |
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