USPIO-Enhanced MR imaging of glycerol-induced acute renal failure in the rabbit |
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| Institution: | 1. Emergency Department, Academic Hospital of Parma, Parma, Italy;2. NYU Langone Medical Center, Leon H. Charney Division of Cardiology, New York University School of Medicine, New York, USA;3. Department of Physiology, Faculty of Medicine, University of Valencia and Fundación Investigación Hospital Clínico Universitario de Valencia, Instituto de Investigación INCLIVA, Valencia, Spain;4. Laboratory of Clinical Chemistry and Hematology, University Hospital of Verona, Verona, Italy;5. Section of Clinical Chemistry, University of Verona, Verona, Italy;1. Advent Health Orlando, Orlando, FL, United States of America;2. Orange Regional Medical Center, Middletown, NY, United States of America;3. St Joseph''s University Medical Center, Paterson, NJ, United States of America |
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| Abstract: | Enhanced-MR imaging in combination with ultrasmall superparamagnetic iron oxide (USPIO) was used in the glycerol-induced model of acute renal failure (ARF) in the rabbit to detect renal perfusion abnormalities. A control group (n = 5) and an ARF group (n = 5) were studied after intramuscular injection of glycerol (10 ml/kg) with T2-weighted spin-echo sequence at 1.5 T and a 27 μmol/kg IV dose of iron. The signal intensity (SI) was quantified in the cortex, the outer medulla (OM), and the inner medulla (IM). In control rabbits, the maximum SI decrease after USPIO injection was in the OM (76% ± 3.6), as this is the region of maximal vascular density, then in the IM (73.4% ± 2.9). In the glycerol group, SI loss in the OM (61% ± 12.6) and the IM (45.2% ± 16.24) was significant less than in the control group (p < .05). Pathology results showed fibrinous thrombus in the efferent arterioles and congestive aspect of the vasa recta in the medulla. We argue that a reduced medullary concentration of USPIO in the renal failure group is indicative of medullary hypoperfusion. |
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