Cobalt-Catalyzed Asymmetric Hydrogenation: Substrate Specificity and Mechanistic Variability |
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Authors: | Dr. Soumyadeep Chakrabortty Prof. Dr. Bas de Bruin Prof. Dr. Johannes G. de Vries |
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Affiliation: | 1. Leibniz-Institut für Katalyse e.V., Albert-Einstein-Straße 29a, 18059 Rostock, Germany;2. Van ‘t Hoff Institute for Molecular Sciences (HIMS), Science Park 904, 1098 XH Amsterdam, The Netherlands |
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Abstract: | Asymmetric hydrogenation finds widespread application in academia and industry. And indeed, a number of processes have been implemented for the production of pharma and agro intermediates as well as flavors & fragrances. Although these processes are all based on the use of late transition metals as catalysts, there is an increasing interest in the use of base metal catalysis in view of their lower cost and the expected different substrate scope. Catalysts based on cobalt have already shown their potential in enantioselective hydrogenation chemistry. This review outlines the impressive progress made in recent years on cobalt-catalyzed asymmetric hydrogenation of different unsaturated substrates. We also illustrate the ligand dependent substrate specificity as well as the mechanistic variability in detail. This may well guide further catalyst development in this research area. |
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Keywords: | Cobalt Homogeneous Catalysis Hydrogenation Ligands Mechanism |
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