微通道反应器在不对称催化中的应用

不对称催化是合成手性化合物的重要手段，针对该领域已开展了大量的研究工作并获得了引人瞩目的研究成果。相比于传统的釜式反应器，微通道反应器具有传质/传热效率高、反应时间短、易于自动化和提高安全性等优势。因此，将微通道反应器应用于不对称催化领域已成为当前的研究热点，并且在耦合在线分析、多相催化和光催化等领域已展现出良好的应用前景。本文对近年来微通道反应器在不对称催化领域中的最新研究进展进行总结和综述，并对未来的发展方向进行展望。

Application Progress of Microreactors in Asymmetric Catalysis

Asymmetric catalysis is a significant method to synthesize chiral compounds. Extensive research efforts have been carried out for asymmetric catalysis, which has obtained remarkable results. Compared with the batchwise counterpart, asymmetric catalysis in microreactors have the advantages of excellent mass- and heat- transfer, decreasing residence time, facile automation and improving safety. Therefore, application of microreactors in asymmetric catalysis has become a current research hotspot. And there have been successful examples in integrated online analysis, heterogeneous catalysis and photocatalysis. This review mainly summarizes the recent progress in asymmetric catalysis in microreactors with chiral organocatalysts and chiral metal complexes. And the prospects of further development are proposed.