Pharmacodynamic Differential Serum Chromatography for Identifying the Pharmacodynamic Material Basis of a Traditional Chinese Medicine |
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Authors: | Wang Chao Xiao Qian Li Yuwen Yang Zhifu Wu Yin Jia Yanyan Qiao Yi Xi Miaomiao Wen Aidong |
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Institution: | 1.Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, 17 Chang Le Xi Road Xi’an, Shaanxi, People’s Republic of China ;2.Department of Dermatology, Xijing Hospital, Fourth Military Medical University, 17 Chang Le Xi Road, Xi’an, Shaanxi, People’s Republic of China ; |
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Abstract: | The modernization and marketing of traditional Chinese medicine is difficult primarily because its pharmacodynamic material basis has not been elucidated. Moreover, a central problem is the lack of effective research methods and strategies. After >20 years of study, here, we propose the theory of pharmacodynamic differential serum chromatography. The method described here can be used to identify (and possibly develop) effective pharmacodynamic materials. In light of the theory, we identified hydroxysafflor yellow A (HSYA) to be the effective pharmacodynamic material of Carthamus tinctorius L. (safflower). With the help of the methodology described here, the modernization and understanding of traditional Chinese medicine may be accelerated. |
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