Investigation of the tautomeric equilibrium of nucleic acid bases in aqueous solution |
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| Authors: | G. N. Ten V. I. Baranov |
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| Affiliation: | (1) N. G. Chernyshevskii Saratov State University, Russia;(2) V. I. Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences, Moscow |
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| Abstract: | Relative constants of acidity and basicity of nucleic acid bases (NABs) and their tautomeric forms are calculated. The general characteristic of the effect of an aqueous solvent on the tautomeric equilibrium of NABs is formulated. It is shown that during the tautomeric transformation of NABs their acid-base properties change to the opposite ones. One of possible causes of the formation of complementary pairs with rare tautomeric forms of NABs is considered. |
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| Keywords: | bases of nucleic acids aqueous solution tautomers relative constants of acidity and basicity modeling calculation mutations in DNA |
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