Synthesis and characterization of biodegradable amphiphilic PEG-grafted poly(DTC-co-CL) |
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Authors: | Qiu Jin Zhang Wei Pu Zhu Zhi Quan Shen |
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Affiliation: | MOE Key Laboratory of Macromolecule Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China |
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Abstract: | A novel biodegradable copolymer, poly(5,5-dibromomethyltrimethylene carbonate-co-ε-caprolactone) (poly(DBTC-co-CL)) with pendant bromine groups, was synthesized via ring-opening polymerization (ROP) of ε-caprolactone (CL) and 5,5-dibromomethyltrimethylene carbonate (DBTC) using stannous octoate (Sn(Oct)2) as catalyst. Then the pendant bromine groups were completely converted into azide form, which permitted “click” reaction with alkyne-terminated polyethylene (A-PEG) by Huisgen 1,3-dipolar cycloadditions preparing biodegradable amphiphilic poly(DTC-co-CL)-g-PEG graft copolymer. The graft copolymer was characterized by nuclear magnetic resonance (NMR) and size exclusion chromatography (SEC). |
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Keywords: | Polycarbonate “Click”reaction Graft copolymer Ring-opening polymerization |
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