Two-photon microscopy study of the intracellular compartmentalisation of emissive terbium complexes and their oligo-arginine and oligo-guanidinium conjugates |
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Authors: | Kielar Filip Congreve Aileen Law Ga-lai New Elizabeth J Parker David Wong Ka-Leung Castreno Pilar de Mendoza Javier |
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Affiliation: | Department of Chemistry, Durham University, South Road, Durham, UKDH1 3LE. |
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Abstract: | An emissive terbium complex has been conjugated to a C12 chain, Lys-Arg7, Arg7, a tetraguanidinium cation and human serum albumin; two-photon excitation at 720 nm facilitated microscopy studies revealing cell localisation profiles with the oligo-guanidinium conjugate localising in mitochondria but causing apoptotic cell death (IC(50)12 microM), the C12-amide complex giving rise to necrotic cell death in skin fibroblasts (IC50 8 microM) and the peptide conjugates and the methyl ester generating punctuate cytosolic intracellular distributions. |
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