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Ruthenium-catalyzed glycine-selective oxidative backbone modification of peptides |
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| Authors: | Shun-Ichi Murahashi Akira Mitani Kyuuhei Kitao |
| Affiliation: | Department of Chemistry, Graduate School of Engineering Science, Osaka University, Machikaneyama 1-3, Toyonaka, Osaka 560-8531, Japan |
| Abstract: | The reaction of N,C-protected peptides containing glycine residues with peracetic acid in the presence of a ruthenium catalyst gives -ketoamides derived from the oxidation at the C position of the glycine residues selectively. |
| Keywords: | oxidation peptide glycine backbone modification ruthenium catalyst |
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