Copper-catalyzed rearrangement of vinyl oxiranes |
| |
Authors: | Batory Lindsay A McInnis Christine E Njardarson Jon T |
| |
Institution: | Department of Chemistry and Chemical Biology, Baker Laboratory, Cornell University, Ithaca, New York 14853-1301, USA. |
| |
Abstract: | A novel copper-catalyzed vinyl oxirane ring expansion protocol has been developed. A wide range of vinyl oxiranes can be rearranged to 2,5-dihydrofurans in excellent yields in the presence of electrophilic copper(II) acetylacetonate catalysts. Regioisomeric vinyl oxiranes can be converted to a single dihydrofuran product using these conditions. This method uses low catalyst loadings (0.5-5 mol %), has good tolerance of substitution patterns, and can be done in the absence of solvent. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|