| DOPA在聚乙烯微孔膜上的自聚合及肝素固定化 |
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| 引用本文： | 朱利平,徐又一,奚振宇,朱宝库. DOPA在聚乙烯微孔膜上的自聚合及肝素固定化[J]. 高分子学报, 2009, 0(4): 394-397. DOI: 10.3724/SP.J.1105.2009.00394 |
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| 作者姓名： | 朱利平 徐又一 奚振宇 朱宝库 |
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| 作者单位： | 浙江大学高分子科学研究所,大分子合成与功能构造教育部重点实验室,杭州,310027 |
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| 基金项目： | 国家自然科学基金，国家重点基础研究发展规划(973计划) |
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| 摘 要： | 在溶液条件下,左旋3,4-二羟基苯丙氨酸(L-DOPA,或L-多巴)能在固体材料表面自发聚合,形成强力附着于材料表面的poly(DOPA)层.基于L-DOPA的这一特性,对聚乙烯(PE)微孔膜进行了表面改性,得到了PE/poly(DOPA)复合膜,并进一步通过poly(DOPA)层上的反应性基团将肝素共价固载在PE微孔膜上.X光电子能谱(XPS)分析结果证实了poly(DOPA)和肝素的固定,接触角测量数据表明膜的亲水性得到了显著提高.
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| 关 键 词： | 多巴 聚乙烯微孔膜 自聚合 肝素固定 |
| 收稿时间： | 2008-08-05 |
SELF-POLYMERIZATION OF DOPA ON POLYETHYLENE POROUS MEMBRANES AND IMMOBILIZATION OF HEPARIN |
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| ZHU Liping,XU Youyi,XI Zhenyu,ZHU Baoku. SELF-POLYMERIZATION OF DOPA ON POLYETHYLENE POROUS MEMBRANES AND IMMOBILIZATION OF HEPARIN[J]. Acta Polymerica Sinica, 2009, 0(4): 394-397. DOI: 10.3724/SP.J.1105.2009.00394 |
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| Authors: | ZHU Liping XU Youyi XI Zhenyu ZHU Baoku |
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| Affiliation: | Institute of Polymer Science, Key Laboratory of Macromolecule Synthesis and Functionalization, Zhejiang University, Hangzhou 310027 |
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| Abstract: | A new and convenient approach for surface immobilization of heparin onto PE porous membranes is reported.3,4-dihydroxy-L-phenylalanine(L-DOPA),a catecholic amino acid,is an important component of mussel adhesive proteins(MAPs).Based on the strong adhesive behavior of poly(DOPA) on solid surface,hydrophobic PE porous membranes was surface-modified by self-polymerization of L-DOPA in aqueous solution.Subsequently,heparin was immobilized covalently onto PE/poly(DOPA) composite membranes by the coupling between... |
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| Keywords: | DOPA(3 4-dihydroxy-L-phenylalanine) Polyethylene microporous membranes Self-polymerization Heparin immobilization |
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