Synthesis of 1,3,4-thiadiazoles containing the trifluoromethyl group

The following compounds have been synthesized: 2-Amino-5-trifluoromethyl-1,3,4-thiadiazole; N-(5-trifluoromethyl - 1,3,4-thiadizol-2-yl)benzenesulfonamide; N¹-(5-trifluoromethyl-1,3,4-thiadiazol-2-yl)sulfanilamide, its N⁴-acetyl, N⁴-succinyl, and N⁴-pathalyl derivatives; o - m - and p-trifluoromethylbenzoylthiosemicarbazide, their corresponding 2-amino-1,3,4-thiadiazoles, their corresponding sulfanilamides, their N⁴-acetyl, N⁴-succinyl and N⁴-phthalyl derivatives; 3-o-trifluoromethylphenyl-4H-1,2,4-triazole-5-thiol. Preliminary in-vitro assays show that synthesized sulfanilamide derivatives have antibacterial activity against Staphylococcus aureus.