| N-(安替比林-4-基)-N'-取代芳甲酰基硫脲的合成及其生物活性 |
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| 引用本文： | 吴玮琳,叶文法,杨曼丽,汪焱钢.N-(安替比林-4-基)-N'-取代芳甲酰基硫脲的合成及其生物活性[J].有机化学,2005,25(10):1291-1293. |
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| 作者姓名： | 吴玮琳 叶文法 杨曼丽 汪焱钢 |
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| 作者单位： | [1]华中师范大学化学学院,武汉430079 [2]怀化医学专科学校,怀化418000 |
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| 基金项目： | 国家自然科学基金，湖南省教育厅科研项目 |
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| 摘 要： | 合成了12个含安替比林基的取代芳甲酰基硫脲类化合物, 用1H NMR, IR和元素分析确证了它们的结构, 并进行了室内生物活性测试. 生测实验证明部分酰基硫脲类化合物, 比如N-(安替比林-4-基)-N'-m(或o)-甲苯甲酰基硫脲, N-(安替比林-4-基)-N-o-硝基苯甲酰基硫脲, N-(安替比林-4-基)-N'-m(或p)-氯苯甲酰基硫脲, 具有一定的细胞分裂素活性.
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| 关 键 词： | 4-氨基安替比林 酰基硫脲 合成 生物活性 细胞分裂素 |
| 收稿时间： | 12 28 2004 12:00AM |
| 修稿时间： | 04 25 2005 12:00AM |
Synthesis and Biological Activity of N-(Antipyrin-4-yl)-N'-arylformyl Thiourea |
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| WU,Wei-Lin,YE,Wen-Fa,YANG,Man-Li,WANG,Yan-Gang.Synthesis and Biological Activity of N-(Antipyrin-4-yl)-N''-arylformyl Thiourea[J].Chinese Journal of Organic Chemistry,2005,25(10):1291-1293. |
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| Authors: | WU Wei-Lin YE Wen-Fa YANG Man-Li WANG Yan-Gang |
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| Institution: | ( College of Chemistry, Central China Normal University, Wuhan 430079)(Huaihua Medical College, Hunan 418000) |
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| Abstract: | Twelve N-(antipyrin-4-yl)-N'-arylformyl thiourea compounds have been synthesized. Their structures were determined by 1H NMR, IR spectra and elemental analysis. The biological activity tests show that some target compounds, for example, N-(antipyrin-4-yl)-N'-m(or-o)-methylphenylformyl thiourea, N-(antipyrin-4-yl)-N'-o-nitrophenylformyl thiourea and N-(antipyrin-4-yl)-N'-m(or-p)-chlorophenylformyl thiourea, have certain ac-tivity of cytokinin. |
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| Keywords: | 4-aminoantipyrine acylthiourea synthesis biological activity cytokinin |
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