Synthesis of 2,2-dimethyl-1,2-dihydrobenzo[f]-isoquinolines displaying antifungal activity |
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| Authors: | O. V. Surikova A. V. Zachinyaeva A. G. Mikhailovskii Ya. V. Zachinyaev |
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| Affiliation: | (1) Perm State Pharmaceutical Academy, Perm, 614990, Russia;(2) S. M. Kirov Military Medical Academy, Saint Petersburg, 194044, Russia;(3) St Petersburg State Transport University, Saint Petersburg, 190031, Russia; |
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| Abstract: | The reaction of 2,2-dimethyl-1,2-dihydrobenzo[f]isoquinoline with malonic acid gave (2,2-dimethyl-1,2,3,4-tetrahydrobenzo[f]isoquinolin-4-yl)acetic acid, the acid chloride of which readily forms esters with alcohols and phenols. Reaction of the same azomethine with thioglycolic acid leads to (2,2-di-methyl-1,2,3,4-tetrahydro-benzo[f]isoquinolin-4-yl)thioacetic acid. Activation of the initial azomethine by iodomethylation enables reaction with 1,3-indanedione to be carried out. The obtained substances display antifungal action. |
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