Enantioselective Pd-catalyzed hydrogenation of fluorinated imines: facile access to chiral fluorinated amines |
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| Authors: | Chen Mu-Wang Duan Ying Chen Qing-An Wang Duo-Sheng Yu Chang-Bin Zhou Yong-Gui |
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| Affiliation: | State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, China. |
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| Abstract: | An enantioselective hydrogenation of simple fluorinated imines has been developed using Pd(OCOCF(3))(2)/(R)-Cl-MeO-BIPHEP as a catalyst, and up to 94% ee was achieved. This method provides an efficient route to enantioenriched fluorinated amines. |
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