Copper(I)-catalyzed reaction of acylzirconocene chloride: cross-coupling and conjugate addition |
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Authors: | Yuji Hanzawa Kensuke Narita Masaya Yabe Takeo Taguchi |
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Institution: | School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan |
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Abstract: | For the purpose of exploring a new reaction of acylzirconocene chloride as an acyl anion donor, Cu(I)-catalyzed cross-coupling and conjugate addition reactions of acylzirconocene chloride were studied. The coupling reaction with allylic or propargylic halides efficiently proceeded to yield β,γ-unsaturated ketone or allenyl ketone derivatives, respectively. The conjugated addition reaction to ,β-enones was carried out in the presence of 2 equiv. of BF3·OEt2 giving 1,4-diketone compounds. |
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Keywords: | acylzirconocene chloride allenyl ketone propargylic halides |
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