The rheological and structural properties of Fmoc-peptide-based hydrogels: the effect of aromatic molecular architecture on self-assembly and physical characteristics |
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Authors: | Orbach Ron Mironi-Harpaz Iris Adler-Abramovich Lihi Mossou Estelle Mitchell Edward P Forsyth V Trevor Gazit Ehud Seliktar Dror |
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Institution: | Department of Molecular Microbiology and Biotechnology, George S. Wise Faculty of Life Science, Tel-Aviv University, Tel-Aviv 69978, Israel. |
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Abstract: | Biocompatible hydrogels are of high interest as a class of biomaterials for tissue engineering, regenerative medicine, and controlled drug delivery. These materials offer three-dimensional scaffolds to support the growth of cells and development of hierarchical tissue structures. Fmoc-peptides were previously demonstrated as attractive building blocks for biocompatible hydrogels. Here, we further investigate the biophysical properties of Fmoc-peptide-based hydrogels for medical applications. We describe the structural and thermal properties of these Fmoc-peptides, as well as their self-assembly process. Additionally, we study the role of interactions between aromatic moieties in the self-assembly process and on the physical and structural properties of the hydrogels. |
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