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The rheological and structural properties of Fmoc-peptide-based hydrogels: the effect of aromatic molecular architecture on self-assembly and physical characteristics
Authors:Orbach Ron  Mironi-Harpaz Iris  Adler-Abramovich Lihi  Mossou Estelle  Mitchell Edward P  Forsyth V Trevor  Gazit Ehud  Seliktar Dror
Institution:Department of Molecular Microbiology and Biotechnology, George S. Wise Faculty of Life Science, Tel-Aviv University, Tel-Aviv 69978, Israel.
Abstract:Biocompatible hydrogels are of high interest as a class of biomaterials for tissue engineering, regenerative medicine, and controlled drug delivery. These materials offer three-dimensional scaffolds to support the growth of cells and development of hierarchical tissue structures. Fmoc-peptides were previously demonstrated as attractive building blocks for biocompatible hydrogels. Here, we further investigate the biophysical properties of Fmoc-peptide-based hydrogels for medical applications. We describe the structural and thermal properties of these Fmoc-peptides, as well as their self-assembly process. Additionally, we study the role of interactions between aromatic moieties in the self-assembly process and on the physical and structural properties of the hydrogels.
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