The Smart 2-(2-Fluorobenzoyl)-N-(2-Methoxyphenyl)Hydrazinecarbothioamide Functionalized as Ni(II) Sensor in Micromolar Concentration Level and its Application in Live Cell Imaging |
| |
Authors: | Muhammad Saleem Anser Ali Chang-Shik Choi Bong Joo Park Eun Ha Choi Ki Hwan Lee |
| |
Affiliation: | 1. Department of Chemistry, Kongju National University, Gongju, Chungnam, 314-701, Republic of Korea 2. Department of Plasma Bioscience and display, Kwangwoon University, 20 Kwangwoon-gil, Nowon-gu, Seoul, 139-701, Republic of Korea 3. Department of Oriental Medicine Fermentation, Far East University, Eumseong, Chungbuk, 369-700, Republic of Korea
|
| |
Abstract: | In recent years, fluorescent probes for the detection of environmentally and biologically important metal cations have received extensive attention for designing and development of fluorescent chemosensors. Herein, we report the photophysical results of 2-(2-fluorobenzoyl)-N-(2-methoxyphenyl) hydrazinecarbothioamide (4) functionalized as Ni (II) sensor in micromolar concentration level. Through fluorescence titration at 488 nm, we were confirmed that ligand 4 showed the remarkable emission by complexation between 4 and Ni (II) while it appeared no emission in case of the competitive ions (Cr3+, Fe2+, Co2+, Ba2+, Cu2+, Ca2+, Na+, K+, Cu+, Cs+). Furthermore, ligand 4 exhibited no toxicity with precise cell permeability toward normal living cells using L929 cell lines in bio imaging experiment investigated through confocal fluorescence microscope. The non-toxic behavior of ligand 4 (assessed by MTT assay) and its ability to track the Ni2+ in living cells suggest its possibility to use in biological system as nickel sensor. Figure ? |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|